Troy Brouwer and Cam Barker also scored for the Blackhawks, unbeaten in regulation at home (5-0-2). Chicago goalie Nikolai Khabibulin made 24 saves.
Brouwer's goal was his first in 18 NHL games.
Colorado's Adam Foote assisted on Guite's goal, giving him 181 assists with the Avalanche/Nordiques and tying Sandis Ozolinsh's franchise record for defensemen.
Guite scored the lone goal of the first period with 3:38 left on a shot Khabibulin misplayed. Guite's 40-foot drive from the right wing struck Khabibulin's stick, then rolled under him and over the goal line.
Ladd tied it at 1-1 early in the second. From the low edge of the left circle, he ripped in a rebound of Dustin Byfuglien's shot from the slot.
Brouwer's goal gave Chicago a 2-1 lead with 2:19 left in the second. As Brouwer skated to the net, Sharp's shot glanced off the back of his leg. The puck rolled toward the goal and Brouwer stuffed it in.
Barker's power-play goal at 1:21 of the third made it 3-1. His screened drive from the slot slipped between Budaj's pads.
Just less than a minute later, Hejduk cut it to 3-2 on a shot from the right circle that beat Khabibulin just inside the left post.
Sharp made it 4-2 midway through the third when he scored from between the circles to complete a 3-on-2 break.
Ladd fired in his second goal from a sharp angle left of the net with just more than four minutes left to make it 5-2. Sharp's second goal, from the slot, completed the scoring with 2:34 left.
Notes: Blackhawks coach Joel Quenneville faced Colorado for the first time since leaving the Avalanche following the 2007-08 season. Quenneville coached Colorado for three seasons and compiled a 131-92-23 record there, but his contract was not renewed after the Avalanche was eliminated in the second round of the 2008 playoffs. Quenneville replaced Denis Savard as Chicago's coach on Oct. 16, four games into this season. ... Monday's game was the first of five straight at home for Chicago. The Blackhawks' next road game is Nov. 18 at Phoenix when they begin a six-game trip.